TransPath

About TransPath:

TransPath provides data about molecules participating in signal transduction pathways and the reactions they are involved in, resulting in a complex network of interconnected signalling components.

TransPath focuses on signalling cascades that change the activities of transcription factors and thus alter the gene expression profile of a given cell.

The data are well structured with hierarchies among molecules and reactions with either experimentally proven or abstracted reactions with high connectivity. This allows either specific or more general searches and functionalities depending on the needs of the customer. Well evidenced chains of reactions are summarized to predefined pathways distinguishable from the more predictive connections.

Connected and integrated with the TransFac Professional database, TransPath provides a linkage between extra cellular signal molecules (such as hormones, cytokines e.g.c.) and genes responding to these signals.

TransPath tools:

With the software tool PathwayBuilder, any part of the overall network can be retrieved and visualized starting with any molecule or reaction.
The ArrayAnalyzer is a tool for identification of common key regulators in the signaling network. Key regulators can serve as drug targets.

For example, starting from a set of induced genes or corresponding gene products that have been identified in a microarray experiment, the ArrayAnalyzer is applied for retrieving potential drug candidates. The subnets of genes and gene products can be visualized further by the PathwayBuilder™, including their expression heights. The ArrayAnalyzer can also search for common subnetworks or perform statistical functional analyses.

Using TransPath on this server

Transpath records all results of searches to user-specific areas. The main Transpath web page will require logging in with your NIH domain username and password (the same ones used for ITAS, Exchange Email, and my.nih.gov). Enter your username without the prefix (i.e. joeuser, NOT nih\joeuser).

This is a secure server with encrypted communications. When you connect to an application on this server, you may see a popup window about the certificate for this website. Accept the certificate and continue.

Results of TransPath, ExPlain and TransFac searches will be stored on the server for one month, and will be deleted after that.

The databases and tools on this server are available to all NIH personnel. TransFac, TransPath and ExPlain were developed by BioBase International. This server is maintained by the Helix Systems, CIT, NIH.