The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Wednesday, September 30th, 2026
utilization graph
Last 24 hrs
122,519 jobs submitted
90,861 jobs completed
2,318,772 CPU hrs used
22 NIH Institutes
362 Principal Investigators
772 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 7010 papers)

A new AI assisted approach aligns data standards and accelerates interoperability in biomedical research
Long, RA; Ballard, S; Shah, S et al.
NPJ Digit Med , DOI://10.1038/s41746-026-02795-z (2026)


Cytotoxic Microspinosamides from the Marine Sponge Geodia microspinosa That Decrease Diffuse Pleural Mesothelioma Viability
Orfanoudaki, M; Wang, D; Du, L et al.
Mar Drugs , DOI://10.3390/md24090308 (2026)


The Global Parkinson's Disease Genetics (GP2) Genome Browser
Fang, ZH; Grant, RH; Vitale, D et al.
Mov Disord , DOI://10.1002/mds.70309 (2026)


Using Class and Domain Information to Address Domain Shift in Federated Learning
Chiou, CY; Huang, CR; Latour, LL et al.
IEEE Trans Neural Netw Learn Syst , DOI://10.1109/TNNLS.2026.3658584 (2026)


Modeling Friedreich's ataxia with Bergmann glia-enriched human cerebellar organoids
Ryu, S; Inman, J; Hong, H et al.
Commun Biol , DOI://10.1038/s42003-026-10180-5 (2026)


Transduction efficiency in clinical CAR T cell products: A retrospective study at a single center
Shao, L; Prochazkova, M; Cai, Y et al.
Mol Ther Adv , DOI://10.1016/j.omta.2026.201839 (2026)


MetaChrome: an open-source, user-friendly tool for automated metaphase chromosome analysis
Sagar, MAK; Dalal, Y; Pegoraro, G; Arunkumar, G; ,
Methods , DOI://10.1016/j.ymeth.2025.12.013 (2026)


Plasma copeptin is coupled to resting-state frontoinsular-subgenual alpha dynamics in major depression with comorbid post-traumatic stress disorder
Hu, H; Chandler, BH; Sloane, JL et al.
Front Endocrinol (Lausanne) , DOI://10.3389/fendo.2026.1895698 (2026)