The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Saturday, November 7th, 2026
utilization graph
Last 24 hrs
110,590 jobs submitted
93,989 jobs completed
2,135,249 CPU hrs used
26 NIH Institutes
353 Principal Investigators
757 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 7098 papers)

Time-dependent effects of rapid-acting antidepressants in iPSC-derived neurons from treatment-resistant depression and healthy volunteers
Johnston, JN; Jones, GH; Peng, S et al.
Mol Psychiatry , DOI://10.1038/s41380-026-03768-0 (2026)


BAYESIAN SELECTION AND REFITTING OF REFERENCE MUTATIONAL SIGNATURES IN CANCER GENOMICS
Hua, M; Zhu, B; ,
Ann Appl Stat , DOI://10.1214/26-aoas2138 (2026)


Clinical and biochemical characterization of amyotrophic lateral sclerosis in a CHCHD10 R15L family
Kwan, JY; Lantz, CI; Korobeynikov, VA et al.
Brain , DOI://10.1093/brain/awag115 (2026)


Elevated body temperature exacerbates arrhythmia and seizure-like activity in a zebrafish model of Timothy syndrome
Semenova, SA; Sams, AM; Nammi, D et al.
Commun Biol , DOI://10.1038/s42003-026-10657-3 (2026)


Deep learning-based histologic classifiers enable molecular subtyping of metastatic prostate cancer
Chen, Z; Sayar, E; Guevara, D et al.
JCI Insight , DOI://10.1172/jci.insight.201872 (2026)


Therapeutic NAMPT inhibition reveals a targetable metabolic vulnerability in neuroblastoma
Varriano, S; Yu, A; Chakraborty, A et al.
J Exp Clin Cancer Res , DOI://10.1186/s13046-026-03793-5 (2026)


Redox-dependent remodeling of mitochondrial nucleoids contributes to bioenergetic decline during neuronal aging
Cheng, XT; Gao, Y; Chan, CY et al.
Neuron , DOI://10.1016/j.neuron.2026.10.003 (2026)


Brain network-driven predictive neural markers for suicide risk
Lee, Y; Gilbert, JR; Chin Fatt, CR et al.
Front Psychiatry , DOI://10.3389/fpsyt.2026.1950068 (2026)