The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Monday, August 24th, 2026
utilization graph
Last 24 hrs
87,601 jobs submitted
70,816 jobs completed
1,700,111 CPU hrs used
22 NIH Institutes
338 Principal Investigators
712 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6975 papers)

IAN, an intelligent system for omics data analysis and discovery
Nagarajan, V; Horai, R; Shi, G et al.
Cell Rep Methods , DOI://10.1016/j.crmeth.2026.101503 (2026)


Long-read sequencing of single cell-derived melanoma sublines reveals divergent and parallel genomic and epigenomic evolutionary trajectories
Liu, Y; Goretsky, A; Keskus, AG et al.
Nat Commun , DOI://10.1038/s41467-026-75172-9 (2026)


Deletion of ARPKD-associated Pkhd1 gene in mice results in decreased Tfap2b expression and eye abnormalities
Ishimoto, Y; Menezes, LF; Nakaya, N et al.
Nat Commun , DOI://10.1038/s41467-026-75698-y (2026)


Small-molecule modulation of β-arrestins
Kahsai, AW; Pakharukova, N; Kwon, HY et al.
Nature , DOI://10.1038/s41586-026-10683-5 (2026)


Robust structural, kinetic and biophysical characterization of wild-type human ACOD1, selected mutants and their interaction with citraconate
Runge, B; Oktay, H; Fucci, IJ et al.
J Struct Biol X , DOI://10.1016/j.yjsbx.2026.100157 (2026)


Sellar region neurocytomas exhibit a CIMP and neuroendocrine-like epigenetic signature distinct from other intra-axial neurocytomas
Pearce, TM; Cimino, PJ; Lucas, CG et al.
Acta Neuropathol , DOI://10.1007/s00401-026-03070-x (2026)


Alterations in chromatin organization promote totipotent-like features in a DPPA2/DUX-dependent manner
Carey, GI; Vega-Sendino, M; Tillo, D et al.
EMBO J , DOI://10.1038/s44318-026-00853-6 (2026)


Origin and transport of bacterial hopanoids
Lawrence, EC; Pan, H; Ollikainen, N; Belin, BJ; ,
mSystems , DOI://10.1128/msystems.00619-26 (2026)