The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

Current Status     Batch system - The HPC systems are down for scheduled maintenance Jul 29 - Aug 2. https://hpc.nih.gov/nih/about/announcements.php?1207
Biowulf cluster - The HPC systems are down for scheduled maintenance Jul 29 - Aug 2. https://hpc.nih.gov/nih/about/announcements.php?1207
Biowulf login node - The HPC systems are down for scheduled maintenance Jul 29 - Aug 2. https://hpc.nih.gov/nih/about/announcements.php?1207
Filesystems - The HPC systems are down for scheduled maintenance Jul 29 - Aug 2. https://hpc.nih.gov/nih/about/announcements.php?1207
Globus - The HPC systems are down for scheduled maintenance Jul 29 - Aug 2. https://hpc.nih.gov/nih/about/announcements.php?1207
HPC OnDemand - The HPC systems are down for scheduled maintenance Jul 29 - Aug 2. https://hpc.nih.gov/nih/about/announcements.php?1207
HPCDrive - The HPC systems are down for scheduled maintenance Jul 29 - Aug 2. https://hpc.nih.gov/nih/about/announcements.php?1207
Helix - The HPC systems are down for scheduled maintenance Jul 29 - Aug 2. https://hpc.nih.gov/nih/about/announcements.php?1207
Mascot - The HPC systems are down for scheduled maintenance Jul 29 - Aug 2. https://hpc.nih.gov/nih/about/announcements.php?1207
Object Store - The HPC systems are down for scheduled maintenance Jul 29 - Aug 2. https://hpc.nih.gov/nih/about/announcements.php?1207
Partek Flow - The HPC systems are down for scheduled maintenance Jul 29 - Aug 2. https://hpc.nih.gov/nih/about/announcements.php?1207
User Dashboard - The HPC systems are down for scheduled maintenance Jul 29 - Aug 2. https://hpc.nih.gov/nih/about/announcements.php?1207
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Biowulf Utilization
Thursday, July 30th, 2026
utilization graph
Last 24 hrs
75,092 jobs submitted
61,791 jobs completed
1,133,881 CPU hrs used
25 NIH Institutes
342 Principal Investigators
782 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6901 papers)

Developmental stability of task-rest neural efficiency in youth using a threat and cognitive control task
Khosravi, P; Linke, JO; Poe, AD et al.
Front Hum Neurosci , DOI://10.3389/fnhum.2026.1839961 (2026)


Chronic hepatitis D infection is associated with distinguishing microbial and functional features in the gut microbiome
Gewirtz, MA; Zhang, Y; Vaidy, N et al.
Front Microbiol , DOI://10.3389/fmicb.2026.1851892 (2026)


Robust but independent sex differences in human brain function, structure, and behavior
Liu, S; Mahony, BW; Whitman, ET et al.
Nat Commun , DOI://10.1038/s41467-026-73262-2 (2026)


SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children
Xu, Q; Shi, L; , et al.
Nat Commun , DOI://10.1038/s41467-026-72996-3 (2026)


Estimating the heritability of longitudinal rate-of-change: genetic insights into PSA velocity in prostate cancer-free individuals
Zhang, P; Wang, X; Shi, J; Albert, PS; ,
Biostatistics , DOI://10.1093/biostatistics/kxag015 (2026)


Variants in the proteasome regulator PSMF1 cause a phenotypic spectrum from parkinsonism to perinatal lethality
Magrinelli, F; Tesson, C; Angelova, PR et al.
Nat Commun , DOI://10.1038/s41467-026-71351-w (2026)


Artificial intelligence in clinical genetics: current practice and attitudes among the clinical genetics workforce
Berkstresser, AM; Ledgister Hanchard, SE; Iacaboni, D et al.
Genet Med , DOI://10.1016/j.gim.2026.102645 (2026)


ENPP3 CAR T cells combined with CD206 modulation suppress adrenocortical carcinoma
Okada, R; Mendoza, A; Nousome, D et al.
J Immunother Cancer , DOI://10.1136/jitc-2025-013726 (2026)