The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Monday, February 9th, 2026
utilization graph
Last 24 hrs
77,944 jobs submitted
56,452 jobs completed
1,942,365 CPU hrs used
22 NIH Institutes
312 Principal Investigators
684 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6690 papers)

Molecular basis for the regulation of membrane proteins through preferential lipid solvation
Bernhardt, N; Ozturk, TN; Zhang, S et al.
Nat Chem Biol , DOI://10.1038/s41589-025-02032-w (2025)


The Time-Dependent Association Between Irritable Bowel Syndrome and All-Cause and Cause-Specific Mortality in the NIH-AARP Cohort Study
Gutiérrez-Torres, DS; Li, F; Liao, LM et al.
Am J Gastroenterol , DOI://10.14309/ajg.0000000000003861 (2025)


Taxonomic-Level Protein Quantification in Metaproteomics Using a Biomass-Constrained Expectation-Maximization Approach
Alves, G; Hamaneh, MB; Ogurtsov, AY; Yu, YK; ,
J Am Soc Mass Spectrom , DOI://10.1021/jasms.5c00332 (2026)


Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors
Gallanis, AF; Gamble, LA; Oguz, C et al.
Mol Cancer Res , DOI://10.1158/1541-7786.MCR-24-1039 (2025)


An insight into the ovary and midgut transcriptome of Dermacentor nitens tick
Lu, S; Bosio, CF; Andrade-Silva, V et al.
Ticks Tick Borne Dis , DOI://10.1016/j.ttbdis.2025.102600 (2026)


Children's state anxiety before MRI scanning and resting state functional connectivity in large scale brain networks
Qamar, P; Díaz, DE; Benson, BE et al.
Sci Rep , DOI://10.1038/s41598-025-34410-8 (2026)


PCLIPtools: a robust framework for identifying RNA-protein interaction sites from PAR-CLIP experiments
Polash, AH; Hafner, M; ,
Nucleic Acids Res , DOI://10.1093/nar/gkag062 (2026)


Eos plays a critical role in Treg homeostasis and modulates the function of recirculating thymic Tregs in the control of Treg development
Xie, X; Thornton, AM; Tanwar, S et al.
Cell Rep , DOI://10.1016/j.celrep.2025.116838 (2026)