The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Sunday, August 2nd, 2026
utilization graph
Last 24 hrs
31,919 jobs submitted
21,218 jobs completed
397,798 CPU hrs used
21 NIH Institutes
140 Principal Investigators
198 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6941 papers)

Permissive skin microbiomes in WHIM syndrome: HPV and pathogen expansion
Hou, P; Che, Y; Han, J et al.
J Invest Dermatol , DOI://10.1016/j.jid.2026.05.024 (2026)


Using Deep Learning Models of Gene Regulation to Guide Drug Prioritization
Huang, X; Ovcharenko, I; ,
Pharmaceuticals (Basel) , DOI://10.3390/ph19071097 (2026)


High-resolution chromatin mapping reveals that CTCF anchors meiotic loops to the chromosome axis
Cheng, G; Li, X; Brick, K et al.
Nat Commun , DOI://10.1038/s41467-026-73644-6 (2026)


Spatial cellular order underlies locally-confined mechanisms of immune resistance in oropharyngeal cancer
Sievers, C; Robbins, Y; Craveiro, M et al.
Nat Commun , DOI://10.1038/s41467-026-74318-z (2026)


DNA repair drives cisplatin-induced neuronal death
Nathan, WJ; Chen, C; Sakr, R et al.
Cell , DOI://10.1016/j.cell.2026.05.025 (2026)


Fetal organ dose calculator for maternal CT
Morató, S; Yeom, YS; Folio, LR et al.
Med Phys , DOI://10.1002/mp.70602 (2026)


Developmental stability of task-rest neural efficiency in youth using a threat and cognitive control task
Khosravi, P; Linke, JO; Poe, AD et al.
Front Hum Neurosci , DOI://10.3389/fnhum.2026.1839961 (2026)


Mechanism of cytarabine-induced neurotoxicity
Liu, JC; Wang, D; Callen, E et al.
Nature , DOI://10.1038/s41586-025-09210-9 (2025)